TTR antibody (AA 21-147)

Catalog No. ABIN3042346

Product Details anti-TTR Antibody

Target: TTR (Transthyretin (TTR))

Binding Specificity: AA 21-147

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Transthyretin(TTR) detection. Tested with WB, IHC-P in Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Transthyretin(TTR) detection. Tested with WB, IHC-P in Mouse,Rat.
Gene Name: transthyretin
Protein Name: Transthyretin

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived rat Prealbumin recombinant protein (Position: G21-N147). Rat Prealbumin shares 94.5% amino acid (aa) sequence identity with mouse Prealbumin.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: TTR (TTR Products)

Background: Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Synonyms: Amyloid polyneuropathy antibody|Amyloidosis I antibody|ATTR antibody|Carpal tunnel syndrome 1 antibody|CTS antibody|CTS1 antibody| Dysprealbuminemic euthyroidal hyperthyroxinemia antibody|Dystransthyretinemic hyperthyroxinemia antibody|Epididymis luminal protein 111 antibody|HEL111 antibody|HsT2651 antibody|PALB antibody|Prealbumin amyloidosis type I antibody|Prealbumin antibody|Prealbumin Thyroxine-binding antibody|Senile systemic amyloidosis antibody|TBPA antibody|Thyroxine binding prealbumin antibody|Transthyretin antibody|TTHY_HUMAN antibody|TTR antibody|TTR protein antibody

Gene ID: 24856

UniProt: P02767

Pathways: Hormone Transport