STRA8 antibody (AA 341-355)

Catalog No. ABIN3032753

Product Details anti-STRA8 Antibody

Target: STRA8 (Stimulated By Retinoic Acid 8 (STRA8))

Binding Specificity: AA 341-355

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRA8 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids 341-355 (DDDVMLLKCLETFDD-rat) were used as the immunogen for this Stra8 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Stra8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Stra8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for STRA8

Target: STRA8 (Stimulated By Retinoic Acid 8 (STRA8))

Alternative Name: Stra8 (STRA8 Products)

Synonyms: RGD1562852 antibody, stimulated by retinoic acid 8 antibody, stimulated by retinoic acid gene 8 antibody, STRA8 antibody, Stra8 antibody

Background: Stimulated by retinoic acid 8 is expressed in embryonic ovaries just before meiotic initiation, whereas in testis it is expressed after birth. The STRA8 gene contains 9 exons. And this gene is mapped to chromosome 7q31. Retinoic acid (RA) signaling was required for Stra8 expression, and therefore initiation of meiosis, in embryonic mouse ovaries. RA was sufficient to induce expression in embryonic testis. Cyp26-mediated RA metabolism was responsible for delaying expression in embryonic testis. Since RA signaling regulated Stra8 expression in both embryonic ovaries and adult testis, it was said this portion of the meiotic initiation pathway may be identical in both sexes.

UniProt: D4ADQ4