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Nicastrin antibody (N-Term)

NCSTN Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031996
  • Target See all Nicastrin (NCSTN) Antibodies
    Nicastrin (NCSTN)
    Binding Specificity
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 35
    • 31
    • 20
    • 5
    • 5
    • 4
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 49
    • 2
    Rabbit
    Clonality
    • 42
    • 9
    Polyclonal
    Conjugate
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Nicastrin antibody is un-conjugated
    Application
    • 37
    • 13
    • 13
    • 9
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the N-terminus of human NCSTN (VIHVVEKEEDLQWVLTD) was used as the immunogen for this Nicastrin antibody.
    Isotype
    IgG
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    Discover our top product NCSTN Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the Nicastrin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the Nicastrin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    Nicastrin (NCSTN)
    Alternative Name
    Nicastrin (NCSTN Products)
    Synonyms
    CG7012 antibody, Dmel\\CG7012 antibody, Nct antibody, Nic antibody, S5A antibody, ST96B antibody, agro antibody, dNct antibody, nic antibody, NCSTN antibody, DKFZp469O2418 antibody, APH2 antibody, 9430068N19Rik antibody, AA727311 antibody, Aph2 antibody, D1Dau13e antibody, Kiaa0253 antibody, mKIAA0253 antibody, nicastrin antibody, Nicastrin antibody, NCSTN antibody, nct antibody, ncstn antibody, CpipJ_CPIJ001617 antibody, Ncstn antibody, aph-2 antibody
    Background
    Nicastrin, also known as NCSTN, is aproteinthat is a part of the gamma secretase protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretaseprotein complex, all of which undergo significant post-translational modification before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.
    UniProt
    Q92542
    Pathways
    Notch Signaling, Neurotrophin Signaling Pathway
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