LRP5 antibody (C-Term)

Catalog No. ABIN3031640

Product Details anti-LRP5 Antibody

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP5 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Low-density lipoprotein receptor-related protein 5 (IHAVEEVSLEEFSAH) was used as the immunogen for this LRP5 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the LRP5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the LRP5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for LRP5

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Alternative Name: LRP5 (LRP5 Products)

Synonyms: Xlrp5 antibody, bmnd1 antibody, evr1 antibody, evr4 antibody, hbm antibody, lr3 antibody, lrp5-A antibody, lrp7 antibody, oppg antibody, ops antibody, opta1 antibody, vbch2 antibody, LRP5 antibody, LRP6 antibody, BMND1 antibody, EVR1 antibody, EVR4 antibody, HBM antibody, LR3 antibody, LRP7 antibody, OPPG antibody, OPS antibody, OPTA1 antibody, VBCH2 antibody, mKIAA4142 antibody, low-density lipoprotein receptor-related protein 5 antibody, LDL receptor related protein 5 antibody, LDL receptor related protein 5 L homeolog antibody, low density lipoprotein receptor-related protein 5 antibody, LDL receptor related protein 5 like antibody, LOC100147353 antibody, LRP5 antibody, lrp5.L antibody, lrp5 antibody, Lrp5 antibody, LRP5L antibody

Background: Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of Axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.

UniProt: O75197

Pathways: WNT Signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation