ITPR3
Reactivity: Mouse
WB, IF (p), IF (cc)
Host: Rabbit
Polyclonal
AbBy Fluor® 750
Application Notes
The stated application concentrations are suggested starting amounts. Titration of the IP3R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Storage
-20 °C
Storage Comment
After reconstitution, the IP3R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Target
ITPR3
(Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))
Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. IP3R is an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in the gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.