GBP1 antibody (AA 566-589)

Catalog No. ABIN3031133

Product Details anti-GBP1 Antibody

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Binding Specificity: AA 566-589

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids 566-589 (QKESRIMKNEIQDLQTKMRRRKAC-human) were used as the immunogen for this GBP1 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the GBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the GBP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Alternative Name: GBP1 (GBP1 Products)

Synonyms: guanylate binding protein 1 antibody, guanylate binding protein 1, interferon-inducible antibody, guanylate binding protein 1, interferon-inducible, 67kD antibody, GBP1 antibody, Gbp1 antibody, gbp1 antibody

Background: Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of two binding motifs rather than three. The 593-amino acid GBP1 protein shares 77 % and 88 % identity with GBP2 and GBP3, respectively. All GBPs have a conserved N-terminal globular GTP-binding domain containing two consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene localizes to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B.

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin