Glycogen Synthase antibody (pSer641)

Catalog No. ABIN303100

Product Details anti-Glycogen Synthase Antibody

Target: Glycogen Synthase (GYS)

Binding Specificity: pSer641

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glycogen Synthase antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody is specific for the phosphorylated form of GS at S640. Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.

Purification: Immunoaffinity Chromatography.

Immunogen: Human Muscle Glycogen Synthase phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot. Immunoprecipitation. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preserevative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for Glycogen Synthase

Target: Glycogen Synthase (GYS)

Alternative Name: Glycogen Synthase (GYS Products)

Synonyms: CG6940 antibody, Dmel\\CG6904 antibody, anon-WO0118547.108 antibody, glycogen synthase antibody, Glycogen synthase antibody, starch synthase antibody, glgA antibody, GlyS antibody, glgA-2 antibody, glgA-1 antibody, EAMY_RS33325 antibody, Hipma_0956 antibody, Tresu_1353 antibody, Spico_0935 antibody, Trebr_1511 antibody, Mahau_1987 antibody

Background: Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephos-phorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phos-phorylate muscle glycogen synthase.Synonyms: GYS, GYS1, muscle Glycogen Synthase

Gene ID: 2997

NCBI Accession: NP_001155059

UniProt: P13807