DPYD antibody (AA 33-52)

Catalog No. ABIN3030731

Product Details anti-DPYD Antibody

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Binding Specificity: AA 33-52

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYD antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids 33-52 (AKKLDKKHWKRNPDKNCFNC-human) were used as the immunogen for this DPYD antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the DPYD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the DPYD antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for DPYD

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Alternative Name: DPYD (DPYD Products)

Synonyms: DPYD antibody, dpyd antibody, zgc:77205 antibody, AI315208 antibody, DPD antibody, E330028L06Rik antibody, DHP antibody, DHPDHASE antibody, dhp antibody, dhpdhase antibody, dpd antibody, 14.t00017 antibody, DDBDRAFT_0189681 antibody, DDBDRAFT_0231100 antibody, DDB_0189681 antibody, DDB_0231100 antibody, dpyda antibody, zgc:153505 antibody, dihydropyrimidine dehydrogenase antibody, dihydropyrimidine dehydrogenase b antibody, dihydropyrimidine dehydrogenase L homeolog antibody, dihydropyrimidine dehydrogenase [NADP(+)] antibody, dihydropyrimidine dehydrogenase a, tandem duplicate 1 antibody, DPYD antibody, Dpyd antibody, dpydb antibody, dpyd.L antibody, EHI_012980 antibody, LOC5573038 antibody, EDI_044620 antibody, pyd1 antibody, dpyda.1 antibody

Background: Dihydropyrimidine Dehydrogenase, also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the gene was mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the gene is mapped to 1p22. The highest level of DPYD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity could be detected in erythrocytes. The activity of DPYD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process