CYP11B1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
The stated application concentrations are suggested starting amounts. Titration of the CYP11B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Storage
-20 °C
Storage Comment
After reconstitution, the CYP11B1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Target
CYP11B1
(Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))
CPN1 antibody, CYP11B antibody, FHI antibody, P450C11 antibody, AA389061 antibody, Cyp11b antibody, Cyp11b-1 antibody, Cp11ba antibody, RATCP11BA antibody, P450c11 antibody, cytochrome P450, family 11, subfamily B, polypeptide 1 antibody, cytochrome P450 family 11 subfamily B member 1 antibody, cytochrome P450, family 11, subfamily b, polypeptide 1 antibody, cytochrome P450, subfamily XI B, polypeptide 1 antibody, CYP11B1 antibody, Cyp11b1 antibody
Background
Cytochrome p450, family 11, subfamily B, polypeptide 1, also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to convert 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone. CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. mRNA is present in human cardiac tissue samples from left and right atria, aorta, apex, intraventricular septum, and atrioventricular node, as well as whole adult and fetal heart. Ventricles did not express CYP11B1. In patients with 11-beta-hydroxylase deficiency leading to hypertension and congenital adrenal hyperplasia, Pascoe et al. identified mutations in the CYP11B1 gene.