uPAR uPA Receptor (C-Term) antibody

Catalog No. ABIN3029776

Product Details

Target: uPAR uPA Receptor

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human uPAR (CNHPDLDVQYRS) was used as the immunogen for this uPAR antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the uPAR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the uPAR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details

Target: uPAR uPA Receptor

Background: PLAUR (Plasminogen activator receptor, urokinase-type), also known as uPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol(GPI) anchor. It consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. The protein was originally identified as a saturable binding site for urokinase on the cell surface. The gene plays an important role in many normal as well as pathologic processes. It is localized to 19q13.31. uPAR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. It binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane, indicating it is an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a uPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

UniProt: Q03405