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C5A antibody (N-Term)

C5a Reactivity: Rat, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3029692
  • Target See all C5A (C5a) Antibodies
    C5A (C5a) (Complement Component 5a (C5a))
    Binding Specificity
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    • 14
    • 10
    • 7
    • 6
    • 1
    • 1
    Rat, Mouse
    Host
    • 22
    • 14
    • 2
    Rabbit
    Clonality
    • 22
    • 16
    Polyclonal
    Conjugate
    • 23
    • 9
    • 4
    • 1
    • 1
    This C5A antibody is un-conjugated
    Application
    • 36
    • 26
    • 16
    • 13
    • 9
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the N-terminus of rat Complement 5a (DLQLLHQKVEEQAAKYKH) was used as the immunogen for this C5a antibody.
    Isotype
    IgG
    Top Product
    Discover our top product C5a Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the C5a antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the C5a antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    C5A (C5a) (Complement Component 5a (C5a))
    Alternative Name
    C5a Complement 5a (C5a Products)
    Synonyms
    C5a antibody, C5b antibody, CPAMD4 antibody, Hc antibody, RGD1561905 antibody, complement C5 antibody, C5 antibody
    Background
    C5a is a protein fragment released from complement component C5. This gene is mapped to 9q33.2. The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to susceptibility to liver fibrosis and to rheumatoid arthritis.
    Gene ID
    362119
    Pathways
    Complement System, Carbohydrate Homeostasis
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