MYBL2 antibody (N-Term)

Catalog No. ABIN3029533

Product Details anti-MYBL2 Antibody

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYBL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human MYBL2/B-MYB (MSRRTRCEDLDELHYQD) was used as the immunogen for this MYBL2 antibody (100% mouse homology).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the MYBL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the MYBL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for MYBL2

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Alternative Name: MYBL2 (MYBL2 Products)

Synonyms: MYBL2 antibody, bmyb antibody, b-myb antibody, B-Myb antibody, Bmyb antibody, B-MYB antibody, BMYB antibody, myb1 antibody, MYB proto-oncogene like 2 antibody, v-myb avian myeloblastosis viral oncogene homolog-like 2b antibody, myeloblastosis oncogene-like 2 antibody, MYB proto-oncogene like 2 S homeolog antibody, MYBL2 antibody, mybl2 antibody, mybl2b antibody, Mybl2 antibody, mybl2.S antibody

Background: V-MYB avian myeloblastosis viral oncogene homolog-like 2, also called MYB-related gene B-MYB, is a protein that in humans is encoded by the MYBL2 gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. Barletta et al.(1991) assigned the gene to chromosome Xq13. However, Noben-Trauth et al.(1996) demonstrated that this assignment was an error. Using mouse Mybl2 cDNA clones as probes, they assigned the gene in an interspecific backcross panel to distal mouse chromosome 2. Using human cDNA probes in combination with fluorescence in situ hybridization analysis, they localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders and shows high homology of Synteny to mouse chromosome 2. It has been shown to activate the cell division cycle 2, Cyclin D1, and Insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

UniProt: P10244

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, Chromatin Binding