TSACC/C1orf182 antibody (Middle Region)

Catalog No. ABIN3029276

Product Details anti-TSACC/C1orf182 Antibody

Target: TSACC/C1orf182 (TSACC) (TSSK6 Activating Co-Chaperone (TSACC))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSACC/C1orf182 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human SIAH Interacting Protein (NTRWDYLTQVEKECKE) was used as the immunogen for this SIP antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the SIP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SIP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for TSACC/C1orf182

Target: TSACC/C1orf182 (TSACC) (TSSK6 Activating Co-Chaperone (TSACC))

Alternative Name: SIP (TSACC Products)

Synonyms: SIP antibody, TP53DINP1 antibody, TP53INP1A antibody, TP53INP1B antibody, Teap antibody, p53DINP1 antibody, C1orf182 antibody, RP11-443G18.5 antibody, SSTK-IP antibody, 1700021C14Rik antibody, C3H1orf182 antibody, RGD1304953 antibody, tumor protein p53 inducible nuclear protein 1 antibody, TSSK6 activating cochaperone antibody, TSSK6 activating co-chaperone antibody, TP53INP1 antibody, TSACC antibody, Tsacc antibody

Background: CACYBP (Calcyclin-binding protein), also called SIP (SIAH Interacting Protein), is a protein that in humans is encoded by the CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, SIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP protein function.

UniProt: Q9HB71