Histone H2A antibody (pSer139)

Catalog No. ABIN3023622

Product Details anti-Histone H2A Antibody

Target: Histone H2A

Binding Specificity: pSer139

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone H2A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TQASQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around S139 of human Histone H2AX (NP_002096.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1mg/ml

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Histone H2A antibody (ABIN3023622)

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Target Details for Histone H2A

Target: Histone H2A

Abstract: Histone H2A Products

Synonyms: 5499 antibody, CG5499 antibody, Dmel\\CG5499 antibody, H2A antibody, H2A.F/Z antibody, H2A.X antibody, H2A.Z antibody, H2AV antibody, H2AV_DROM antibody, H2AX antibody, H2AZ antibody, H2Av antibody, H2AvD antibody, H2a.V antibody, H2av antibody, H2avD antibody, HIS antibody, HIS2AV antibody, HIS2AVD antibody, His antibody, His2 antibody, His2AV antibody, His2AvD antibody, HisH2Av antibody, Hist antibody, Hist2av antibody, gamma-H2Av antibody, gamma-HIS2AV antibody, gamma-His2Av antibody, gammaH2Av antibody, h2AvD antibody, his antibody, l(3)05146 antibody, l(3)810 antibody, l(3)97Dd antibody, l(3)L1602 antibody, DDBDRAFT_0205974 antibody, DDBDRAFT_0216271 antibody, DDB_0205974 antibody, DDB_0216271 antibody, RGD1564767 antibody, H2a-221 antibody, H2A-III antibody, HIST1H2AA antibody, Histone H2A variant antibody, putative histone H2A antibody, histone H2A antibody, histone cluster 1 H2A family member F antibody, histone H2A-like antibody, histone cluster 1, H2af antibody, histone2A1 antibody, histone cluster 1, H2A, III antibody, histone cluster 1, H2ac antibody, His2Av antibody, LMJF_17_0280 antibody, H2AX antibody, Hist1h2af antibody, LOC100425378 antibody, his2a1 antibody, HIST1H2A3 antibody, HIST1H2AC antibody, h2a-A antibody

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.,H2A.X,H2A/X,H2AX,Histone H2AX,H2AFX,histone H2AX,gamma H2A.X,γH2AX,Epigenetics & Nuclear Signaling,Histones,DNA Damage & Repair,Epigenetics & Nuclear Signaling,Epigenetic Modifications,Phosphorylation,Histone H2A

Molecular Weight: 15 kDa

Gene ID: 3014

UniProt: P16104