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DIABLO antibody (AA 1-232)
DIABLO
Reactivity: Human
WB, IHC, IP
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DIABLO Antibody
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Target
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DIABLO
(Second Mitochondria-Derived Activator of Caspase (DIABLO))
Binding Specificity
All epitopes for DIABLO antibodies
AA 1-232
Reactivity
All reactivities for DIABLO antibodies
Human
Host
All hosts for DIABLO antibodies
Rabbit
Clonality
All clonalities for DIABLO antibodies
Polyclonal
Conjugate
All conjugates for DIABLO antibodies
This DIABLO antibody is un-conjugated
Application
All applications for DIABLO antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Sequence
MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQ
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Purification
Affinity purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human Smac/Smac/Diablo (NP_063940.1).
Isotype
IgG
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Discover our top product DIABLO Primary Antibody
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for DIABLO
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Target
DIABLO
(Second Mitochondria-Derived Activator of Caspase (DIABLO))
Alternative Name
DIABLO (DIABLO Products )
Synonyms
smac antibody, smac3 antibody, diablo-s antibody, 0610041G12Rik antibody, 1700006L01Rik antibody, AU040403 antibody, Smac antibody, DFNA64 antibody, SMAC antibody, DBO antibody, XSmac antibody, diablo, IAP-binding mitochondrial protein antibody, diablo IAP-binding mitochondrial protein antibody, diablo, IAP-binding mitochondrial protein L homeolog antibody, diablo antibody, Diablo antibody, DIABLO antibody, diablo.L antibody
Background
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.,DIABLO,DFNA64,SMAC,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Death receptors & ligands,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,DIABLO
Molecular Weight
21 kDa/22 kDa/27 kDa
Gene ID
56616
UniProt
Q9NR28
Pathways
Apoptosis , Caspase Cascade in Apoptosis , Positive Regulation of Endopeptidase Activity
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