Histone 3 antibody (H3R17me)

Catalog No. ABIN3023283

Product Details anti-Histone 3 Antibody

Target: Histone 3 (H3)

Binding Specificity: H3R17me

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Methylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic methylated peptide corresponding to residues surrounding Arg17 of human histone H3

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Histone 3 antibody (ABIN3023283)

Qiu, Wu, Meng, Luo, Zhao, Sun, Gao: "GYY4137 protects against myocardial ischemia/reperfusion injury via activation of the PHLPP-1/Akt/Nrf2 signaling pathway in diabetic mice." in: The Journal of surgical research, Vol. 225, pp. 29-39, (2018) (PubMed).

Li, Zhu, Wang, Fu, Hou, Ji, Chen, Hu, Shao, Yu, Zhao, Zhang, Du, Bu, Hu, Tang, Zhong, Yang, Zhao, Cen: "Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 37, pp. 12890-902, (2016) (PubMed).

Target Details for Histone 3

Target: Histone 3 (H3)

Alternative Name: Histone H3 (H3 Products)

Synonyms: H-3 antibody, histocompatibility 3 antibody, H3 antibody

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.,HIST1H3J,H3/j,H3FJ,Epigenetics & Nuclear Signaling,Epigenetic Modifications,Methylation,Epigenetics & Nuclear Signaling,Epigenetic Modifications,Methylation,Epigenetics & Nuclear Signaling,Epigenetic Modifications,Methylation,Histone H3

Molecular Weight: 15 kDa

Gene ID: 8356

UniProt: P68431