Presenilin 1 antibody (AA 1-160)

Catalog No. ABIN3023160

Product Details anti-Presenilin 1 Antibody

Target: Presenilin 1 (PSEN1)

Binding Specificity: AA 1-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MTELPAPLSY FQNAQMSEDN HLSNTNDNRE RQEHNDRRSL GHPEPLSNGR PQGNSRQVVE QDEEEDEELT LKYGAKHVIM LFVPVTLCMV VVVATIKSVS FYTRKDGQLI YTPFTEDTET VGQRALHSIL NAAIMISVIV VMTILLVVLY KYRCYKVIHA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Presenilin 1 (NP_015557.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1 (PSEN1 Products)

Synonyms: pre1 antibody, psen antibody, zfPS1 antibody, zf-PS1 antibody, ad3 antibody, fad antibody, ps1 antibody, s182 antibody, X-PS-beta antibody, X-PS-alpha antibody, AD3 antibody, FAD antibody, PS-1 antibody, PS1 antibody, S182 antibody, Ad3h antibody, presenilin 1 antibody, presenilin 1 L homeolog antibody, psen1 antibody, PSEN1 antibody, Psen1 antibody, psen1.L antibody

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.,AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,PSEN1

Molecular Weight: 21 kDa/42 kDa/46 kDa/48 kDa/52 kDa

Gene ID: 5663

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport