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MCM6 antibody (AA 562-821)

MCM6 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3022687
  • Target See all MCM6 Antibodies
    MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
    Binding Specificity
    • 13
    • 8
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    AA 562-821
    Reactivity
    • 44
    • 17
    • 11
    • 10
    • 7
    • 7
    • 7
    • 4
    • 2
    • 1
    • 1
    Human
    Host
    • 35
    • 5
    • 4
    Rabbit
    Clonality
    • 40
    • 4
    Polyclonal
    Conjugate
    • 39
    • 1
    • 1
    • 1
    • 1
    • 1
    This MCM6 antibody is un-conjugated
    Application
    • 38
    • 29
    • 16
    • 14
    • 10
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Sequence
    SIDRVYSLDD IRRYLLFARQ FKPKISKESE DFIVEQYKHL RQRDGSGVTK SSWRITVRQL ESMIRLSEAM ARMHCCDEVQ PKHVKEAFRL LNKSIIRVET PDVNLDQEEE IQMEVDEGAG GINGHADSPA PVNGINGYNE DINQESAPKA SLRLGFSEYC RISNLIVLHL RKVEEEEDES ALKRSELVNW YLKEIESEID SEEELINKKR IIEKVIHRLT HYDHVLIELT QAGLKGSTEG SESYEEDPYL VVNPNYLLED
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 562-821 of human MCM6 (NP_005906.2).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
    Alternative Name
    MCM6 (MCM6 Products)
    Background
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.,MCM6,MCG40308,Mis5,P105MCM,Epigenetics & Nuclear Signaling,MCM6
    Molecular Weight
    92 kDa
    Gene ID
    4175
    UniProt
    Q14566
    Pathways
    DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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