PTPN2 antibody (AA 1-353)
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- Target See all PTPN2 Antibodies
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
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Binding Specificity
- AA 1-353
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PTPN2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Sequence
- MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSERPRL TDT
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PTPN2 (NP_536348.1).
- Isotype
- IgG
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- Application Notes
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
- Alternative Name
- PTPN2 (PTPN2 Products)
- Synonyms
- PTN2 antibody, PTPT antibody, TC-PTP antibody, TCELLPTP antibody, TCPTP antibody, AI325124 antibody, Ptpt antibody, PTP-1B antibody, cb806 antibody, ptpn2 antibody, ptpn2l antibody, wu:fc10h07 antibody, zgc:55339 antibody, zgc:76973 antibody, hm:zeh1546 antibody, zgc:63623 antibody, ptn2 antibody, ptpt antibody, tc-ptp antibody, tcellptp antibody, tcptp antibody, protein tyrosine phosphatase, non-receptor type 2 antibody, protein tyrosine phosphatase, non-receptor type 2 S homeolog antibody, protein tyrosine phosphatase, non-receptor type 2, b antibody, protein tyrosine phosphatase, non-receptor type 2, a antibody, protein tyrosine phosphatase, non-receptor type 2 L homeolog antibody, PTPN2 antibody, Ptpn2 antibody, ptpn2.S antibody, ptpn2b antibody, ptpn2a antibody, ptpn2.L antibody
- Background
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.,PTPN2,PTN2,PTPT,TC-PTP,TCELLPTP,TCPTP,Signal Transduction,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,PTPN2
- Molecular Weight
- 40 kDa/45 kDa/48 kDa
- Gene ID
- 5771
- UniProt
- P17706
- Pathways
- EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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