alpha Adducin antibody (AA 60-300)

Catalog No. ABIN3022200

Product Details anti-alpha Adducin Antibody

Target: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Binding Specificity: AA 60-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha Adducin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MILQSPAFCE ELESMIQEQF KKGKNPTGLL ALQQIADFMT TNVPNVYPAA PQGGMAALNM SLGMVTPVND LRGSDSIAYD KGEKLLRCKL AAFYRLADLF GWSQLIYNHI TTRVNSEQEH FLIVPFGLLY SEVTASSLVK INLQGDIVDR GSTNLGVNQA GFTLHSAIYA ARPDVKCVVH IHTPAGAAVS AMKCGLLPIS PEALSLGEVA YHDYHGILVD EEEKVLIQKN LGPKSKVLIL R

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ADD1 (NP_054908.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for alpha Adducin

Target: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Alternative Name: ADD1 (ADD1 Products)

Background: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms, however, not all variants have been fully described.,ADD1,ADDA,adducin 1,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cytoskeleton,Neuroscience,Calcium Signaling,ADD1

Molecular Weight: 56 kDa/69 kDa/73 kDa/80 kDa/84 kDa

Gene ID: 118

UniProt: P35611

Pathways: Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling