TIMP3 antibody (AA 24-211)

Catalog No. ABIN3022043

Product Details anti-TIMP3 Antibody

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Binding Specificity: AA 24-211

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: CTCSPSHPQD AFCNSDIVIR AKVVGKKLVK EGPFGTLVYT IKQMKMYRGF TKMPHVQYIH TEASESLCGL KLEVNKYQYL LTGRVYDGKM YTGLCNFVER WDQLTLSQRK GLNYRYHLGC NCKIKSCYYL PCFVTSKNEC LWTDMLSNFG YPGYQSKHYA CIRQKGGYCS WYRGWAPPDK SIINATDP

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TIMP3 antibody (ABIN3022043)

Liu, Zhang, Yao, Xie, Dai, Zhang, Zhou: "Serum extracellular vesicles promote proliferation of H9C2 cardiomyocytes by increasing miR-17-3p." in: Biochemical and biophysical research communications, Vol. 499, Issue 3, pp. 441-446, (2018) (PubMed).

Target Details for TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Alternative Name: TIMP3 (TIMP3 Products)

Background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.,TIMP3,HSMRK222,K222,K222TA2,SFD,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Extracellular Matrix,MMPs,Ubiquitin,Neuroscience,Cardiovascular,Angiogenesis,TIMP3

Molecular Weight: 24 kDa

Gene ID: 7078

UniProt: P35625