CBS antibody (AA 252-551)

Catalog No. ABIN3021959

Product Details anti-CBS Antibody

Target: CBS (Cystathionine-beta-Synthase (CBS))

Binding Specificity: AA 252-551

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBS antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: VASVGTGGTI TGIARKLKEK CPGCRIIGVD PEGSILAEPE ELNQTEQTTY EVEGIGYDFI PTVLDRTVVD KWFKSNDEEA FTFARMLIAQ EGLLCGGSAG STVAVAVKAA QELQEGQRCV VILPDSVRNY MTKFLSDRWM LQKGFLKEED LTEKKPWWWH LRVQELGLSA PLTVLPTITC GHTIEILREK GFDQAPVVDE AGVILGMVTL GNMLSSLLAG KVQPSDQVGK VIYKQFKQIR LTDTLGRLSH ILEMDHFALV VHEQIQYHST GKSSQRQMVF GVVTAIDLLN FVAAQERDQK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 252-551 of human CBS (NP_000062.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-CBS antibody (ABIN3021959)

Niu, Wang, Qian, Wang, Wu, Chen, Yan: "Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond." in: The Journal of biological chemistry, Vol. 293, Issue 7, pp. 2523-2533, (2018) (PubMed).

Seale, Ha, Hashimoto, Berry: "Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism." in: Free radical biology & medicine, Vol. 127, pp. 182-189, (2018) (PubMed).

Target Details for CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Alternative Name: CBS (CBS Products)

Synonyms: hip4 antibody, GB12529 antibody, CBS antibody, DDBDRAFT_0189727 antibody, DDBDRAFT_0191292 antibody, DDB_0189727 antibody, DDB_0191292 antibody, cbs antibody, AI047524 antibody, AI303044 antibody, HIP4 antibody, cb442 antibody, wu:fb37g05 antibody, wu:fm61c07 antibody, wu:fq06c06 antibody, zgc:113704 antibody, cystathionine-beta-synthase L homeolog antibody, cystathionine-beta-synthase antibody, cystathionine beta-synthase antibody, cystathionine beta-synthase CBS antibody, cystathionine beta synthase antibody, cystathionine-beta-synthase S homeolog antibody, cystathionine-beta-synthase b antibody, cbs.L antibody, cbs antibody, Cbs antibody, CBS antibody, CNA06170 antibody, Tb11.02.5400 antibody, cysB antibody, LOC100635325 antibody, cbs.S antibody, cbsb antibody

Background: The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.,CBS,HIP4,Cancer,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,CBS

Molecular Weight: 60 kDa/61 kDa

Gene ID: 875

UniProt: P35520