CD44 antibody (AA 35-300)

Catalog No. ABIN3021913

Product Details anti-CD44 Antibody

Target: CD44

Binding Specificity: AA 35-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: HVEKNGRYSI SRTEAADLCK AFNSTLPTMA QMEKALSIGF ETCRYGFIEG HVVIPRIHPN SICAANNTGV YILTSNTSQY DTYCFNASAP PEEDCTSVTD LPNAFDGPIT ITIVNRDGTR YVQKGEYRTN PEDIYPSNPT DDDVSSGSSS ERSSTSGGYI FYTFSTVHPI PDEDSPWITD STDRIPATST SSNTISAGWE PNEENEDERD RHLSFSGSGI DDDEDFISST ISTTPRAFDH TKQNQDWTQW NPSHSNPEVL LQTTTR

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-300 of human CD44 (NP_001001389.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-CD44 antibody (ABIN3021913)

Ji, Yang, Tang, Yang, Tian, Yao, Zhu, Zhang, Ji, Zheng: "Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation." in: Nature communications, Vol. 8, pp. 15308, (2018) (PubMed).

Target Details for CD44

Target: CD44

Alternative Name: CD44 (CD44 Products)

Synonyms: CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody

Background: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,CD44,CD44,Cancer,Tumor immunology,Tumor biomarkers,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells,CD44

Molecular Weight: 3 kDa/15 kDa/32-53 kDa/73-81 kDa

Gene ID: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling