HFE antibody (AA 80-306)

Catalog No. ABIN3021896

Product Details anti-HFE Antibody

Target: HFE (Hemochromatosis (HFE))

Binding Specificity: AA 80-306

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HFE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSQMWLQLSQ SLKGWDHMFT VDFWTIMENH NHSKESHTLQ VILGCEMQED NSTEGYWKYG YDGQDHLEFC PDTLDWRAAE PRAWPTKLEW ERHKIRARQN RAYLERDCPA QLQQLLELGR GVLDQQVPPL VKVTHHVTSS VTTLRCRALN YYPQNITMKW LKDKQPMDAK EFEPKDVLPN GDGTYQGWIT LAVPPGEEQR YTCQVEHPGL DQPLIVIWEP SPSGTLV

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-306 of human HFE (NP_000401.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HFE

Target: HFE (Hemochromatosis (HFE))

Alternative Name: HFE (HFE Products)

Synonyms: HFE1 antibody, HH antibody, HLA-H antibody, MVCD7 antibody, TFQTL2 antibody, MR2 antibody, hemochromatosis antibody, HFE antibody, Hfe antibody

Background: The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.,HFE,HFE1,HH,HLA-H,MVCD7,TFQTL2,Signal Transduction,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases Markers,Other Neurological disorders,Stem Cells,Hematopoietic Progenitors,Amyotrophic lateral sclerosis-ALS,HFE

Molecular Weight: 8 kDa/18 kDa/27-40 kDa

Gene ID: 3077

UniProt: Q30201

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process