TYR antibody (AA 20-340)

Catalog No. ABIN3021852

Product Details anti-TYR Antibody

Target: TYR (Tyrosinase (TYR))

Binding Specificity: AA 20-340

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: FPRACVSSKN LMEKECCPPW SGDRSPCGQL SGRGSCQNIL LSNAPLGPQF PFTGVDDRES WPSVFYNRTC QCSGNFMGFN CGNCKFGFWG PNCTERRLLV RRNIFDLSAP EKDKFFAYLT LAKHTISSDY VIPIGTYGQM KNGSTPMFND INIYDLFVWM HYYVSMDALL GGSEIWRDID FAHEAPAFLP WHRLFLLRWE QEIQKLTGDE NFTIPYWDWR DAEKCDICTD EYMGGQHPTN PNLLSPASFF SSWQIVCSRL EEYNSHQSLC NGTPEGPLRR NPGNHDKSRT PRLPSSADVE FCLSLTQYES GSMDKAANFS F

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-340 of human TYR (NP_000363.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TYR antibody (ABIN3021852)

Zhang, Wang, Yu, Jiang, Yue, Liu: "Identification of a gene encoding microphthalmia-associated transcription factor and its association with shell color in the clam Meretrix petechialis." in: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, Vol. 225, pp. 75-83, (2018) (PubMed).

Target Details for TYR

Target: TYR (Tyrosinase (TYR))

Alternative Name: TYR (TYR Products)

Synonyms: sandy antibody, zgc:109705 antibody, TYR antibody, TYRO antibody, tyr antibody, LOC100136546 antibody, CMM8 antibody, OCA1A antibody, OCAIA antibody, SHEP3 antibody, albino antibody, c antibody, skc35 antibody, C antibody, tyrosinase antibody, TYRosinase antibody, tyrosinase S homeolog antibody, tyr antibody, tyr-5 antibody, tyr.S antibody, TYR antibody, Celal_3121 antibody, Halhy_4121 antibody, Mesop_2736 antibody, LOC100136546 antibody, Tyr antibody

Background: The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.,TYR,ATN,CMM8,OCA1,OCA1A,OCAIA,SHEP3,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,TYR

Molecular Weight: 42 kDa/60 kDa

Gene ID: 7299

UniProt: P14679