ALDH2 antibody (AA 1-380)

Catalog No. ABIN3021779

Product Details anti-ALDH2 Antibody

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Binding Specificity: AA 1-380

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS RKTFPTVNPS TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH RGRLLNRLAD LIERDRTYLA ALETLDNGKP YVISYLVDLD MVLKCLRYYA GWADKYHGKT IPIDGDFFSY TRHEPVGVCG QIIPWNFPLL MQAWKLGPAL ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG FGPTAGAAIA SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN PFDSKTEQGP QVDETQFKKI LGYINTGKQE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human ALDH2 (NP_000681.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ALDH2 antibody (ABIN3021779)

Yan, Lestari, Long, Fan, Wang, Guo, Yu, Hu, Yang, Chen, Liu, Li, Purnomoadi, Achmadi, Yan: "Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells." in: Scientific reports, Vol. 6, pp. 23340, (2017) (PubMed).

Long, Muhamad, Yan, Yu, Fan, Wang, Li, Purnomoadi, Achmadi, Yan: "Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells." in: Amino acids, Vol. 48, Issue 5, pp. 1297-307, (2017) (PubMed).

Target Details for ALDH2

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Alternative Name: ALDH2 (ALDH2 Products)

Synonyms: aldh2 antibody, aldh2a antibody, zgc:63786 antibody, MGC80785 antibody, aldh-e2 antibody, aldhi antibody, aldm antibody, rf2b antibody, ALDH-E2 antibody, ALDHI antibody, ALDM antibody, Ahd-5 antibody, Ahd5 antibody, aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 antibody, aldehyde dehydrogenase 2 family (mitochondrial) L homeolog antibody, aldehyde dehydrogenase 2 family (mitochondrial) antibody, aldehyde dehydrogenase 2 antibody, aldehyde dehydrogenase antibody, aldehyde dehydrogenase (NAD(+)) antibody, hypothetical protein antibody, aldehyde dehydrogenase 2, mitochondrial antibody, aldh2.1 antibody, aldh2.L antibody, aldh2 antibody, ALDH2 antibody, RHA1_RS43090 antibody, aldH2 antibody, OE_RS03015 antibody, Aldh2 antibody

Background: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,ALDH2,ALDH-E2,ALDHI,ALDM,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Cardiovascular,Heart,Cardiac metabolism,ALDH2

Molecular Weight: 50 kDa/56 kDa

Gene ID: 217

UniProt: P05091