MCM7 antibody (AA 360-719)

Catalog No. ABIN3021521

Product Details anti-MCM7 Antibody

Target: MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))

Binding Specificity: AA 360-719

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequence: GGVDQSPRGM KIRGNINICL MGDPGVAKSQ LLSYIDRLAP RSQYTTGRGS SGVGLTAAVL RDSVSGELTL EGGALVLADQ GVCCIDEFDK MAEADRTAIH EVMEQQTISI AKAGILTTLN ARCSILAAAN PAYGRYNPRR SLEQNIQLPA ALLSRFDLLW LIQDRPDRDN DLRLAQHITY VHQHSRQPPS QFEPLDMKLM RRYIAMCREK QPMVPESLAD YITAAYVEMR REAWASKDAT YTSARTLLAI LRLSTALARL RMVDVVEKED VNEAIRLMEM SKDSLLGDKG QTARTQRPAD VIFATVRELV SGGRSVRFSE AEQRCVSRGF TPAQFQAALD EYEELNVWQV NASRTRITFV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 360-719 of human MCM7 (NP_005907.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MCM7

Target: MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))

Alternative Name: MCM7 (MCM7 Products)

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.,MCM7,CDC47,MCM2,P1.1-MCM3,P1CDC47,P85MCM,PNAS146,PPP1R104,Epigenetics & Nuclear Signaling,MCM7

Molecular Weight: 44 kDa/60 kDa/81 kDa

Gene ID: 4176

UniProt: P33993

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA