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FAM3B antibody (AA 30-235)

FAM3B Reactivity: Human IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3021391
  • Target See all FAM3B Antibodies
    FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 30-235
    Reactivity
    • 40
    • 22
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 51
    • 5
    Rabbit
    Clonality
    • 53
    • 3
    Polyclonal
    Conjugate
    • 23
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FAM3B antibody is un-conjugated
    Application
    • 44
    • 23
    • 13
    • 13
    • 11
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequence
    ELIPDAPLSS AAYSIRSIGE RPVLKAPVPK RQKCDHWTPC PSDTYAYRLL SGGGRSKYAK ICFEDNLLMG EQLGNVARGI NIAIVNYVTG NVTATRCFDM YEGDNSGPMT KFIQSAAPKS LLFMVTYDDG STRLNNDAKN AIEALGSKEI RNMKFRSSWV FIAAKGLELP SEIQREKINH SDAKNNRYSG WPAEIQIEGC IPKERS
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human FAM3B (NP_478066.3).
    Isotype
    IgG
    Top Product
    Discover our top product FAM3B Primary Antibody
  • Application Notes
    IHC,1:100 - 1:200,IF,1:100 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))
    Alternative Name
    FAM3B (FAM3B Products)
    Synonyms
    2-21 antibody, C21orf11 antibody, C21orf76 antibody, ORF9 antibody, PANDER antibody, 9030624C24Rik antibody, D16Jhu19e antibody, Pander antibody, RGD1311662 antibody, family with sequence similarity 3 member B antibody, family with sequence similarity 3, member B antibody, FAM3B antibody, Fam3b antibody
    Target Type
    Viral Protein
    Background
    FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.,FAM3B,2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Immunology & Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway,FAM3B
    Molecular Weight
    20 kDa/25 kDa/30 kDa
    Gene ID
    54097
    UniProt
    P58499
    Pathways
    Hormone Transport
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