FAM3B antibody (AA 30-235)

Catalog No. ABIN3021391

Product Details anti-FAM3B Antibody

Target: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Binding Specificity: AA 30-235

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM3B antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: ELIPDAPLSS AAYSIRSIGE RPVLKAPVPK RQKCDHWTPC PSDTYAYRLL SGGGRSKYAK ICFEDNLLMG EQLGNVARGI NIAIVNYVTG NVTATRCFDM YEGDNSGPMT KFIQSAAPKS LLFMVTYDDG STRLNNDAKN AIEALGSKEI RNMKFRSSWV FIAAKGLELP SEIQREKINH SDAKNNRYSG WPAEIQIEGC IPKERS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human FAM3B (NP_478066.3).

Isotype: IgG

Application Details

Application Notes: IHC,1:100 - 1:200,IF,1:100 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FAM3B

Target: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Alternative Name: FAM3B (FAM3B Products)

Target Type: Viral Protein

Background: FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.,FAM3B,2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Immunology & Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway,FAM3B

Molecular Weight: 20 kDa/25 kDa/30 kDa

Gene ID: 54097

UniProt: P58499

Pathways: Hormone Transport