TPMT antibody (AA 1-245)

Catalog No. ABIN3021279

Product Details anti-TPMT Antibody

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Binding Specificity: AA 1-245

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPMT antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRCLEKV DAFEERHKSW GIDCLFEKLY LLTEK

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:10 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT (TPMT Products)

Background: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.,TPMT,TPMTD,Signal Transduction,Endocrine & Metabolism,Drug metabolism,TPMT

Molecular Weight: 28 kDa

Gene ID: 7172

UniProt: P51580