Endothelin 1 antibody (AA 18-212)

Catalog No. ABIN3021076

Product Details anti-Endothelin 1 Antibody

Target: Endothelin 1 (EDN1)

Binding Specificity: AA 18-212

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: APETAVLGAE LSAVGENGGE KPTPSPPWRL RRSKRCSCSS LMDKECVYFC HLDIIWVNTP EHVVPYGLGS PRSKRALENL LPTKATDREN RCQCASQKDK KCWNFCQAGK ELRAEDIMEK DWNNHKKGKD CSKLGKKCIY QQLVRGRKIR RSSEEHLRQT RSETMRNSVK SSFHDPKLKG KPSRERYVTH NRAHW

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-212 of human Endothelin 1 (NP_001946.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: EDN1 (EDN1 Products)

Synonyms: et1 antibody, et-1 antibody, Edn1 antibody, EDN antibody, ET-1 antibody, ET1 antibody, PPET1 antibody, HDLCQ7 antibody, preproET antibody, Et1 antibody, fb14d01 antibody, wu:fb14d01 antibody, PPET-1 antibody, EDN1 antibody, edn1 antibody, edn1-a antibody, edn1-b antibody, endothelin 1 antibody, endothelin 1 S homeolog antibody, endothelin 1 L homeolog antibody, edn1 antibody, EDN1 antibody, Edn1 antibody, edn1.S antibody, edn1.L antibody

Background: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.,EDN1,ARCND3,ET1,HDLCQ7,PPET1,QME,endothelin-1,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Cardiovascular,Angiogenesis,Hypoxia,EDN1

Molecular Weight: 24 kDa

Gene ID: 1906

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size