HSP70 1A antibody (C-Term)

Catalog No. ABIN3020878

Product Details anti-HSP70 1A Antibody

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP70 1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: NALESYAFNM KSAVEDEGLK GKISEADKKK VLDKCQEVIS WLDANTLAEK DEFEHKRKEL EQVCNPIISG LYQGAGGPGP GGFGAQGPKG GSGSGPTIEE VD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 540 to the C-terminus of human HSP70/HSPA1 (NP_005336.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-HSP70 1A antibody (ABIN3020878)

Ding, Chen, Zhang, Huang, Zang, Li, Li, Wong: "Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery." in: The Journal of biological chemistry, Vol. 291, Issue 38, pp. 20125-35, (2017) (PubMed).

Geng, Li, Huang, Chai, Zheng, Li, Jiang: "Functional analysis of HSPA1A and HSPA8 in parturition." in: Biochemical and biophysical research communications, Vol. 483, Issue 1, pp. 371-379, (2017) (PubMed).

Wang, Yu, Wang, Li, Li, Wang, Song, Chu, Li: "Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing." in: Biomaterials, Vol. 78, pp. 27-39, (2016) (PubMed).

Zhou, Jiang, Dong, Yan, You, Su, Gong: "The proteins interacting with C-terminal of μ receptor are identified by bacterial two-hybrid system from brain cDNA library in morphine-dependent rats." in: Life sciences, Vol. 143, pp. 156-67, (2016) (PubMed).

Ye, Chen, Zhang, Miao, Zohaib, Xu, Chen, Cao: "Heat shock protein 70 is associated with replicase complex of Japanese encephalitis virus and positively regulates viral genome replication." in: PLoS ONE, Vol. 8, Issue 9, pp. e75188, (2013) (PubMed).

Target Details for HSP70 1A

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Alternative Name: HSPA1A (HSPA1A Products)

Background: This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.,HSPA1A,HEL-S-103,HSP70-1,HSP70-1A,HSP70.1,HSP70I,HSP72,HSPA1,HSP70,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Endocrine & Metabolism,Mitochondrial metabolism,Neuroscience,Neurodegenerative Diseases,HSPA1A

Molecular Weight: 70 kDa

Gene ID: 3303

UniProt: P0DMV8

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process