IGF1R antibody (AA 660-760)

Catalog No. ABIN3020768

Product Details anti-IGF1R Antibody

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Binding Specificity: AA 660-760

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF1R antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HNYCSKDKIP IRKYADGTID IEEVTENPKT EVCGGEKGPC CACPKTEAEK QAEKEEAEYR KVFENFLHNS IFVPRPERKR RDVMQVANTT MSSRSRNTTA A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 660-760 of human IGF1R (NP_000866.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-IGF1R antibody (ABIN3020768)

Duan, Zohaib, Li, Zhu, Ye, Wan, Xu, Song, Chen, Cao: "miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes." in: Cellular signalling, Vol. 27, Issue 1, pp. 61-8, (2015) (PubMed).

Huang, Dong, Sui, Hu, Xiong, Liao, Zhang: "MiR-223 suppresses endometrial carcinoma cells proliferation by targeting IGF-1R." in: American journal of translational research, Vol. 6, Issue 6, pp. 841-9, (2015) (PubMed).

Target Details for IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF1R (IGF1R Products)

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,IGF1R,CD221,IGFIR,IGFR,JTK13,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Apoptosis,Growth factor,Insulin and insulin-like,ESC Pluripotency and Differentiation,Immunology & Inflammation,CD markers,Cardiovascular,Angiogenesis,IGF1R

Molecular Weight: 154 kDa

Gene ID: 3480

UniProt: P08069

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy