alpha Fetoprotein antibody (AA 360-609)

Catalog No. ABIN3020666

Product Details anti-alpha Fetoprotein Antibody

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Binding Specificity: AA 360-609

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha Fetoprotein antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RRHPQLAVSV ILRVAKGYQE LLEKCFQTEN PLECQDKGEE ELQKYIQESQ ALAKRSCGLF QKLGEYYLQN AFLVAYTKKA PQLTSSELMA ITRKMAATAA TCCQLSEDKL LACGEGAADI IIGHLCIRHE MTPVNPGVGQ CCTSSYANRR PCFSSLVVDE TYVPPAFSDD KFIFHKDLCQ AQGVALQTMK QEFLINLVKQ KPQITEEQLE AVIADFSGLL EKCCQGQEQE VCFAEEGQKL ISKTRAALGV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 360-609 of human Alpha-Fetoprotein (Alpha-Fetoprotein (AFP)) (NP_001125.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-alpha Fetoprotein antibody (ABIN3020666)

Shen, Li, Zhang, Guo, Zhang, Zheng, Teng, Zhou, Guo, Huo: "A Comparative Proteome Profile of Female Mouse Gonads Suggests a Tight Link between the Electron Transport Chain and Meiosis Initiation." in: Molecular & cellular proteomics : MCP, Vol. 17, Issue 1, pp. 31-42, (2019) (PubMed).

Ma, Zhu, Tan, Mao, Tang, Shen, Zhang, Kuang, Fei, Yang, Wang: "Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway." in: American journal of cancer research, Vol. 7, Issue 3, pp. 433-447, (2017) (PubMed).

Target Details for alpha Fetoprotein

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Alternative Name: AFP (AFP Products)

Synonyms: FETA antibody, HPAFP antibody, alpha fetoprotein antibody, alpha-fetoprotein antibody, AFP antibody, Afp antibody

Background: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.,AFPD,FETA,HPAFP,AFP,Cancer,Tumor biomarkers,Cell Biology & Developmental Biology,Stem Cells,Cardiovascular,Blood,Serum Proteins,AFP

Molecular Weight: 68 kDa

Gene ID: 174

UniProt: P02771

Pathways: C21-Steroid Hormone Metabolic Process