CHRNA10 antibody (AA 25-240)

Catalog No. ABIN3017240

Product Details anti-CHRNA10 Antibody

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Binding Specificity: AA 25-240

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA10 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AEGRLALKLF RDLFANYTSA LRPVADTDQT LNVTLEVTLS QIIDMDERNQ VLTLYLWIRQ EWTDAYLRWD PNAYGGLDAI RIPSSLVWRP DIVLYNKADA QPPGSASTNV VLRHDGAVRW DAPAITRSSC RVDVAAFPFD AQHCGLTFGS WTHGGHQLDV RPRGAAASLA DFVENVEWRV LGMPARRRVL TYGCCSEPYP DVTFTLLLRR RAAAYV

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CHRNA10

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Alternative Name: CHRNA10 (CHRNA10 Products)

Synonyms: si:dkey-24p1.3 antibody, ALPHA 10 nAChR antibody, cholinergic receptor, nicotinic, alpha polypeptide 10 antibody, cholinergic receptor nicotinic alpha 10 subunit antibody, cholinergic receptor, nicotinic, alpha 10a antibody, neuronal acetylcholine receptor subunit alpha-10 antibody, cholinergic receptor, nicotinic, alpha 10 (neuronal) antibody, Chrna10 antibody, CHRNA10 antibody, chrna10a antibody, LOC100344381 antibody

Background: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.,CHRNA10,Signal Transduction,Neuroscience,Calcium Signaling,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,CHRNA10

Molecular Weight: 49 kDa

Gene ID: 57053

UniProt: Q9GZZ6

Pathways: Sensory Perception of Sound, Synaptic Membrane