GRPR antibody (AA 235-384)

Catalog No. ABIN3017022

Product Details anti-GRPR Antibody

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Binding Specificity: AA 235-384

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRPR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KNLIQSAYNL PVEGNIHVKK QIESRKRLAK TVLVFVGLFA FCWLPNHVIY LYRSYHYSEV DTSMLHFVTS ICARLLAFTN SCVNPFALYL LSKSFRKQFN TQLLCCQPGL IIRSHSTGRS TTCMTSLKST NPSVATFSLI NGNICHERYV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GRPR

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Alternative Name: GRPR (GRPR Products)

Synonyms: GRPR antibody, GRP-R antibody, gastrin releasing peptide receptor antibody, GRPR antibody, Grpr antibody

Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.,GRPR,BB2,BB2R,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,GRPR

Molecular Weight: 43 kDa

Gene ID: 2925

UniProt: P30550