ATG4B
Reactivity: Human
WB, IF, ICC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB,1:500 - 1:2000
Restrictions
For Research Use only
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Li, Zhao, Wang, Shao, Wang, Wang, Xing: "Regulation of autophagy factors by oxidative stress and cardiac enzymes imbalance during arsenic or/and copper induced cardiotoxicity in Gallus gallus." in: Ecotoxicology and environmental safety, Vol. 148, pp. 125-134, (2018) (PubMed).
Sun, Li, Zhao, Wang, Liu, Shao, Xue, Xing: "Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus." in: Journal of inorganic biochemistry, Vol. 178, pp. 54-62, (2018) (PubMed).
Shao, Zhao, Wang, Liu, Zong, Xing: "Copper-Mediated Mitochondrial Fission/Fusion Is Associated with Intrinsic Apoptosis and Autophagy in the Testis Tissues of Chicken." in: Biological trace element research, (2018) (PubMed).
Shao, Zhao, Wang, Liu, Li, Luo, Xing: "The apoptosis in arsenic-induced oxidative stress is associated with autophagy in the testis tissues of chicken." in: Poultry science, Vol. 97, Issue 9, pp. 3248-3257, (2018) (PubMed).
Target
ATG4B
(Autophagy related 4B Cysteine Peptidase (ATG4B))
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Background
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.,ATG4B,APG4B,AUTL1,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Autophagy,Extracellular Matrix,Ubiquitin,Endocrine & Metabolism,Mitochondrial metabolism,Cardiovascular,Heart,ATGs,ATG4B