TNK2 antibody (AA 70-385)

Catalog No. ABIN3016190

Product Details anti-TNK2 Antibody

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Binding Specificity: AA 70-385

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TGWLLELLSE VQLQQYFLRL RDDLNVTRLS HFEYVKNEDL EKIGMGRPGQ RRLWEAVKRR KALCKRKSWM SKVFSGKRLE AEFPPHHSQS TFRKTSPAPG GPAGEGPLQS LTCLIGEKDL RLLEKLGDGS FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT FSHASDTWMF GVTLWE

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 70-385 of human TNK2 (NP_001010938.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TNK2 antibody (ABIN3016190)

Hu, Xu, Yin, Zhang, Lu, Wu, Xue, Ho, Gao, Zhao, Zhang: "Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded." in: Cell discovery, Vol. 2, pp. 15047, (2016) (PubMed).

Target Details for TNK2

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Alternative Name: TNK2 (TNK2 Products)

Synonyms: ACK antibody, ACK-1 antibody, ACK1 antibody, p21cdc42Hs antibody, AW552477 antibody, Ack antibody, Cdgip antibody, Pyk1 antibody, ack1 antibody, ackb antibody, tnk2 antibody, tnk2b antibody, wu:fj16g04 antibody, zgc:154019 antibody, tyrosine kinase non receptor 2 antibody, tyrosine kinase, non-receptor, 2 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK2 antibody, Tnk2 antibody, tnk1 antibody

Background: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.,TNK2,ACK,ACK-1,ACK1,p21cdc42Hs,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Cell Cycle,Growth factor,EGF,TNK2

Molecular Weight: 60 kDa/114 kDa/119 kDa

Gene ID: 10188

UniProt: Q07912