BRCA2 antibody (AA 1-300)

Catalog No. ABIN3016069

Product Details anti-BRCA2 Antibody

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MPIGSKERPT FFEIFKTRCN KADLGPISLN WFEELSSEAP PYNSEPAEES EHKNNNYEPN LFKTPQRKPS YNQLASTPII FKEQGLTLPL YQSPVKELDK FKLDLGRNVP NSRHKSLRTV KTKMDQADDV SCPLLNSCLS ESPVVLQCTH VTPQRDKSVV CGSLFHTPKF VKGRQTPKHI SESLGAEVDP DMSWSSSLAT PPTLSSTVLI VRNEEASETV FPHDTTANVK SYFSNHDESL KKNDRFIASV TDSENTNQRE AASHGFGKTS GNSFKVNSCK DHIGKSMPNV LEDEVYETVV

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BRCA2 (NP_000050.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Alternative Name: BRCA2 (BRCA2 Products)

Synonyms: BRCC2 antibody, BROVCA2 antibody, FACD antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD antibody, FANCD1 antibody, GLM3 antibody, PNCA2 antibody, 30169 antibody, BcDNA:SD25109 antibody, CG13583 antibody, CG13584 antibody, CG30169 antibody, Dmel\\CG30169 antibody, brca2 antibody, dmbrca2 antibody, fancd1 antibody, BRCA2 antibody, brcc2 antibody, brovca2 antibody, facd antibody, fad antibody, fad1 antibody, fancb antibody, AI256696 antibody, AW045498 antibody, Fancd1 antibody, RAB163 antibody, BRCA2, DNA repair associated antibody, Breast cancer 2, early onset homolog antibody, breast cancer 2, early onset antibody, BRCA2 antibody, Brca2 antibody, brca2 antibody, LOC584780 antibody

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.,BRCA2,BRCC2,BROVCA2,FACD,FAD,FAD1,FANCD,FANCD1,GLM3,PNCA2,XRCC11,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,BRCA2

Molecular Weight: 384 kDa

Gene ID: 675

UniProt: P51587

Pathways: DNA Damage Repair, M Phase, Maintenance of Protein Location