Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-350) antibody
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- Target See all Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antibodies
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
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Binding Specificity
- AA 1-350
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CBLB (NP_733762.2).
- Isotype
- IgG
- Top Product
- Discover our top product CBLB Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
- Alternative Name
- CBLB (CBLB Products)
- Synonyms
- rnf56 antibody, cblb antibody, AI429560 antibody, AI851073 antibody, Cbl-b antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog antibody, Casitas B-lineage lymphoma b antibody, Cbl proto-oncogene B antibody, cblb.S antibody, cblb.L antibody, Cblb antibody, CBLB antibody
- Background
- E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor, BCR (B-cell receptor and FCER1 (high affinity immunoglobulin epsilon receptor signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA signaling pathway via ubiquitination and internalization of PDGFRA (By similarity.,CBLB,Cbl-b,Nbla00127,RNF56,Cancer,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,CBLB
- Molecular Weight
- 86 kDa/90 kDa/109 kDa
- Gene ID
- 868
- UniProt
- Q13191
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