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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-350) antibody

CBLB Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3015830
  • Target See all Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antibodies
    Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
    Binding Specificity
    • 15
    • 9
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-350
    Reactivity
    • 35
    • 27
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 46
    • 4
    Rabbit
    Clonality
    • 46
    • 4
    Polyclonal
    Conjugate
    • 18
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 42
    • 19
    • 13
    • 13
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CBLB (NP_733762.2).
    Isotype
    IgG
    Top Product
    Discover our top product CBLB Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
    Alternative Name
    CBLB (CBLB Products)
    Synonyms
    rnf56 antibody, cblb antibody, AI429560 antibody, AI851073 antibody, Cbl-b antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog antibody, Casitas B-lineage lymphoma b antibody, Cbl proto-oncogene B antibody, cblb.S antibody, cblb.L antibody, Cblb antibody, CBLB antibody
    Background
    E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor, BCR (B-cell receptor and FCER1 (high affinity immunoglobulin epsilon receptor signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA signaling pathway via ubiquitination and internalization of PDGFRA (By similarity.,CBLB,Cbl-b,Nbla00127,RNF56,Cancer,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,CBLB
    Molecular Weight
    86 kDa/90 kDa/109 kDa
    Gene ID
    868
    UniProt
    Q13191
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