FMO3 antibody (AA 263-532)

Catalog No. ABIN3015686

Product Details anti-FMO3 Antibody

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Binding Specificity: AA 263-532

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: RFKHENYGLM PLNGVLRKEP VFNDELPASI LCGIVSVKPN VKEFTETSAI FEDGTIFEGI DCVIFATGYS FAYPFLDESI IKSRNNEIIL FKGVFPPLLE KSTIAVIGFV QSLGAAIPTV DLQSRWAAQV IKGTCTLPSM EDMMNDINEK MEKKRKWFGK SETIQTDYIV YMDELSSFIG AKPNIPWLFL TDPKLAMEVY FGPCSPYQFR LVGPGQWPGA RNAILTQWDR SLKPMQTRVV GRLQKPCFFF HWLKLFAIPI LLIAVFLVLT

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3 (NP_001002294.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:10 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FMO3

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Alternative Name: FMO3 (FMO3 Products)

Synonyms: MGC107820 antibody, FMOII antibody, TMAU antibody, dJ127D3.1 antibody, FM03 antibody, AW111792 antibody, flavin containing monooxygenase 3 antibody, flavin containing monooxygenase 3 L homeolog antibody, FMO3 antibody, fmo3 antibody, fmo3.L antibody, Fmo3 antibody

Background: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.,FMO3,FMOII,TMAU,dJ127D3.1,Signal Transduction,Endocrine & Metabolism,Drug metabolism,FMO3

Molecular Weight: 60 kDa

Gene ID: 2328

UniProt: P31513