OPTN antibody (AA 1-577)

Catalog No. ABIN3015613

Product Details anti-OPTN Antibody

Target: OPTN (Optineurin (OPTN))

Binding Specificity: AA 1-577

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPTN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequence: MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP_068815.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for OPTN

Target: OPTN (Optineurin (OPTN))

Alternative Name: OPTN (OPTN Products)

Synonyms: nrp antibody, fip2 antibody, hip7 antibody, hypl antibody, glc1e antibody, tfiiia-intp antibody, ALS12 antibody, FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP antibody, TFIIIA-INTP antibody, Fip2 antibody, 4930441O07Rik antibody, fj52f04 antibody, si:ch211-240l19.3 antibody, wu:fj52f04 antibody, zgc:66386 antibody, zgc:77868 antibody, optineurin antibody, optineurin L homeolog antibody, OPTN antibody, optn antibody, Optn antibody, optn.L antibody

Background: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.,OPTN,ALS12,FIP2,GLC1E,HIP7,HYPL,NRP,TFIIIA-INTP,Signal Transduction,Immunology & Inflammation,Cytokines,TNF,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,OPTN

Molecular Weight: 59 kDa/65 kDa

Gene ID: 10133

UniProt: Q96CV9

Pathways: M Phase