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C5 antibody (C-Term)

C5 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2856818
  • Target See all C5 Antibodies
    C5 (Complement Component 5 (C5))
    Binding Specificity
    • 21
    • 15
    • 15
    • 15
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 124
    • 32
    • 19
    • 16
    • 2
    • 2
    • 2
    Human
    Host
    • 110
    • 18
    • 6
    • 4
    Rabbit
    Clonality
    • 120
    • 17
    Polyclonal
    Conjugate
    • 51
    • 13
    • 11
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C5 antibody is un-conjugated
    Application
    • 70
    • 50
    • 43
    • 39
    • 26
    • 19
    • 12
    • 10
    • 7
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Characteristics
    Rabbit Polyclonal antibody to C5 (complement component 5)
    C5 antibody [C2C3-2], C-term
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human C5. The exact sequence is proprietary.
    Isotype
    IgG
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    Discover our top product C5 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: H1299

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    C5 (Complement Component 5 (C5))
    Alternative Name
    complement C5 (C5 Products)
    Synonyms
    C5 antibody, LOC565774 antibody, C5a antibody, C5b antibody, CPAMD4 antibody, Hc antibody, RGD1561905 antibody, He antibody, complement C5 antibody, complement component 5 antibody, hemolytic complement antibody, C5 antibody, c5 antibody, Hc antibody
    Background
    The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

    Cellular Localization: Secreted
    Molecular Weight
    188 kDa
    Gene ID
    727
    UniProt
    P01031
    Pathways
    Complement System, Carbohydrate Homeostasis
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