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PCMT1 antibody

PCMT1 Reactivity: Human WB, IF, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2856765
  • Target See all PCMT1 Antibodies
    PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))
    Reactivity
    • 53
    • 26
    • 19
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 49
    • 5
    Rabbit
    Clonality
    • 49
    • 5
    Polyclonal
    Conjugate
    • 25
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PCMT1 antibody is un-conjugated
    Application
    • 36
    • 13
    • 13
    • 11
    • 10
    • 10
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Characteristics
    Rabbit Polyclonal antibody to PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)
    PCMT1 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human PCMT1. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product PCMT1 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: 293T

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.96 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))
    Alternative Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1 Products)
    Synonyms
    PIMT antibody, C79501 antibody, PCM antibody, PCMT antibody, etID309741.20 antibody, fj13d06 antibody, pimt antibody, wu:fj13d06 antibody, protein-L-isoaspartate (D-aspartate) O-methyltransferase antibody, protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 antibody, protein-L-isoaspartate (D-aspartate) O-methyltransferase L homeolog antibody, protein-L-isoaspartate(D-aspartate)O-methyltransferase antibody, PCMT1 antibody, Pcmt1 antibody, pcmt1.L antibody, pcmt1 antibody, pcmt antibody
    Background
    Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM]

    Molecular Weight
    25 kDa
    Gene ID
    5110
    UniProt
    P22061
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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