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F13A1 antibody (N-Term)

F13A1 Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2856753
  • Target See all F13A1 Antibodies
    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
    Binding Specificity
    • 22
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 79
    • 8
    • 7
    • 3
    • 3
    Human
    Host
    • 47
    • 32
    • 3
    • 1
    Rabbit
    Clonality
    • 50
    • 33
    Polyclonal
    Conjugate
    • 52
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This F13A1 antibody is un-conjugated
    Application
    • 48
    • 45
    • 30
    • 29
    • 22
    • 19
    • 15
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Rabbit polyclonal antibody to Factor XIIIa (coagulation factor XIII, A1 polypeptide)
    Factor XIIIa antibody [N1N3]
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the N-terminus region of human Factor XIIIa. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product F13A1 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.97 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
    Alternative Name
    coagulation factor XIII A chain (F13A1 Products)
    Synonyms
    F13a antibody, f13a1 antibody, wu:fo83d04 antibody, zgc:153334 antibody, F13A1 antibody, F13A antibody, 1200014I03Rik antibody, AI462306 antibody, coagulation factor XIII A1 chain antibody, coagulation factor XIII, A1 polypeptide b antibody, coagulation factor XIII A chain antibody, coagulation factor XIII, A1 subunit antibody, F13a1 antibody, f13a1b antibody, F13A1 antibody
    Background
    This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

    Cellular Localization: Cytoplasm , Secreted
    Molecular Weight
    83 kDa
    Gene ID
    2162
    UniProt
    P00488
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