Lamin B2 antibody

Catalog No. ABIN2856712

Product Details anti-Lamin B2 Antibody

Target: Lamin B2 (LMNB2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to Lamin B2 (lamin B2)
Lamin B2 antibody [N3C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Lamin B2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:40000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Neuro2A , GL261 , C8D30 , NIH-3T3 , BCL-1 , Raw264.7 , C2C12

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.73 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for Lamin B2

Target: Lamin B2 (LMNB2)

Alternative Name: lamin B2 (LMNB2 Products)

Synonyms: lmnb2-a antibody, LMNB2 antibody, lmn2 antibody, lamb2 antibody, Lamin-L(II) antibody, LOC100136040 antibody, im:7142331 antibody, lamin antibody, wu:fb94e05 antibody, wu:fb95e12 antibody, wu:fc15d06 antibody, wu:fc49h03 antibody, lamin-b2 antibody, lmnb2 antibody, LAMB2 antibody, LMN2 antibody, RGD1563803 antibody, lamin B2 S homeolog antibody, lamin B2 antibody, lamin B2 L homeolog antibody, lmnb2.S antibody, LMNB2 antibody, lmnb2 antibody, lmnb2.L antibody, Lmnb2 antibody

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. This gene is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene.

Cellular Localization: Nucleus inner membrane, Lipid-anchor, Nucleoplasmic side

Molecular Weight: 68 kDa

Gene ID: 84823

UniProt: Q03252

Pathways: Apoptosis, Caspase Cascade in Apoptosis