FGD4 antibody

Catalog No. ABIN2856709

Product Details anti-FGD4 Antibody

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to FGD4 (FYVE, RhoGEF and PH domain containing 4)
FGD4 antibody [N1N3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human FGD4. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Molt-4

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Alternative Name: FYVE, RhoGEF and PH domain containing 4 (FGD4 Products)

Synonyms: CMT4H antibody, FRABP antibody, ZFYVE6 antibody, 9030023J02Rik antibody, 9330209B17Rik antibody, Frabp antibody, FYVE, RhoGEF and PH domain containing 4 antibody, FGD4 antibody, Fgd4 antibody

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.

Cellular Localization: Cytoplasm , cytoskeleton (By similarity) , Cell projection , filopodium (By similarity)

Molecular Weight: 87 kDa

Gene ID: 121512

UniProt: Q96M96

Pathways: Neurotrophin Signaling Pathway