PDE4C antibody

Catalog No. ABIN2856292

Product Details anti-PDE4C Antibody

Target: PDE4C (phosphodiesterase 4C, CAMP-Specific (PDE4C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to PDE4C (phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila))
PDE4C antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PDE4C. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.67 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for PDE4C

Target: PDE4C (phosphodiesterase 4C, CAMP-Specific (PDE4C))

Alternative Name: phosphodiesterase 4C (PDE4C Products)

Synonyms: im:7160317 antibody, pde4c antibody, si:dkey-149i17.5 antibody, PDE4C antibody, dpde1 antibody, Dpde1 antibody, E130301F19Rik antibody, dunce antibody, DPDE1 antibody, phosphodiesterase 4C antibody, phosphodiesterase 4C, cAMP-specific a antibody, phosphodiesterase 4C, cAMP specific antibody, PDE4C antibody, pde4ca antibody, pde4c antibody, Pde4c antibody

Background: Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4C is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).[supplied by OMIM]

Molecular Weight: 80 kDa

Gene ID: 5143

UniProt: Q08493

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process