GLRA1 antibody

Catalog No. ABIN2856259

Product Details anti-GLRA1 Antibody

Target: GLRA1 (Glycine Receptor, alpha 1 (GLRA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLRA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Rat

Characteristics: Rabbit Polyclonal antibody to Glycine Receptor alpha1 (glycine receptor, alpha 1)
Glycine Receptor alpha1 antibody [N1C1]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Glycine Receptor alpha 1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLaS3

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.43 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for GLRA1

Target: GLRA1 (Glycine Receptor, alpha 1 (GLRA1))

Alternative Name: glycine receptor alpha 1 (GLRA1 Products)

Synonyms: GLYRA1 antibody, HKPX1 antibody, STHE antibody, [a]Z1 antibody, B230397M16Rik antibody, nmf11 antibody, oscillator antibody, ot antibody, spasmodic antibody, spd antibody, glycine receptor alpha 1 antibody, glycine receptor, alpha 1 antibody, glycine receptor, alpha 1 subunit antibody, GLRA1 antibody, Glra1 antibody, glra1 antibody

Background: The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Cell junction , synapse , postsynaptic cell membrane, Multi-pass membrane protein , Cell membrane, Multi-pass membrane protein

Molecular Weight: 53 kDa

Gene ID: 2741

UniProt: P23415

Pathways: Synaptic Membrane