STAM antibody (Center)
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- Target See all STAM Antibodies
- STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))
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Binding Specificity
- Center
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This STAM antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Mouse (Murine), Xenopus laevis, Cow (Bovine), Xenopus tropicalis
- Cross-Reactivity (Details)
- Mouse (96 %), Xenopus laevis (88 %), Bovine (97 %), Xenopus tropicalis (90 %)
- Characteristics
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Rabbit Polyclonal antibody to STAM (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1)
STAM antibody - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human STAM. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product STAM Primary Antibody
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- Application Notes
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
- Comment
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Positive Control: 293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))
- Alternative Name
- STAM (STAM Products)
- Synonyms
- STAM-1 antibody, STAM1 antibody, wu:fv75b10 antibody, zgc:55725 antibody, RGD1564499 antibody, signal transducing adaptor molecule antibody, signal transducing adapter molecule 1 antibody, Signal transducing adapter molecule 1 antibody, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody, STAM antibody, CpipJ_CPIJ003516 antibody, Tsp_03939 antibody, stam-1 antibody, Stam antibody, stam antibody
- Background
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This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.
Cellular Localization: Cytoplasm (Probable) , Early endosome membrane, Peripheral membrane protein, Cytoplasmic side - Molecular Weight
- 59 kDa
- Gene ID
- 8027
- Pathways
- EGFR Signaling Pathway, EGFR Downregulation
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