MAPKAP Kinase 3 antibody
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- Target See all MAPKAP Kinase 3 (MAPKAPK3) Antibodies
- MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MAPKAP Kinase 3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Cross-Reactivity
- Human, Mouse
- Characteristics
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Rabbit Polyclonal antibody to MAPKAP Kinase 3 (mitogen-activated protein kinase-activated protein kinase 3)
MAPKAP Kinase 3 antibody [N2C3] - Purification
- Purified by antigen-affinity chromatography.
- Grade
- KO Validated
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human MAPKAP Kinase 3. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product MAPKAPK3 Primary Antibody
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- Application Notes
- WB: 1:500-1:20000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: Mouse spleen , H1299 , HeLaS3 , HeLa
Validation: KO/KD
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))
- Alternative Name
- mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3 Products)
- Synonyms
- 3PK antibody, MAPKAP-K3 antibody, MAPKAP3 antibody, MAPKAPK-3 antibody, MK-3 antibody, AI874665 antibody, MK3 antibody, MapkKapk3 antibody, MAPKAPK3 antibody, mapkapk3 antibody, MGC154360 antibody, 3pk antibody, mapkap3 antibody, zgc:158342 antibody, mitogen-activated protein kinase-activated protein kinase 3 antibody, mitogen-activated protein kinase-activated protein kinase 3 S homeolog antibody, MAPKAPK3 antibody, Mapkapk3 antibody, mapkapk3.S antibody, mapkapk3 antibody
- Background
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This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
Cellular Localization: Nucleus , Cytoplasm - Molecular Weight
- 43 kDa
- Gene ID
- 7867
- UniProt
- Q16644
- Pathways
- MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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